Research


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Research project (§ 26 & § 27)
Duration : 2017-10-01 - 2020-09-30

Functional polymer chains covalently bond to wood are able to provide wood a completely new set of characteristics. In order to control and design distribution and functionality of the introduced functional polymers, new characterization technologies are needed. Chemical-force microscopy was identified as key-methodology capable of monitoring a wide range of functional groups, their distribution at the required high resolution and function in gaseous as well as in liquid ambient.
Research project (§ 26 & § 27)
Duration : 2017-07-01 - 2019-06-30

Cellular DNA is tightly packed with histones, proteins directly involved in regulation of gene expression with impact on numerous biological processes including cell differentiation, epigenetics and disease development. In particular, histones achieve this regulation by various types and combinations of post-translational modifications that are interpreted by interactions with specific effector proteins. Despite their pivotal role in different biological contexts, effects of histone modifications on recruitment of effectors at the atomistic level remains elusive. Here, our main goal is to further our understanding of microscopic mechanisms determining the function of histone modifications. To do this, we will use molecular dynamics simulations, a widely used high-resolution computational method for studying biomolecular properties and behavior at the atomistic level. More specifically, we intend to systematically investigate how different histone modifications and combinations thereof affect interactions with related effectors. In addition, histone effectors dedicated to recognition of lysine methylation and acetylation have been recently shown as promising targets for small molecule drugs. To this end, we intend to use molecular dynamics simulations to model interactions of effectors with known active molecules in order to examine binding mechanism as well as explore binding of other compounds by using perturbation free energy calculations.
Research project (§ 26 & § 27)
Duration : 2017-07-01 - 2018-03-31

The lifetime of wind power plants is limited by failure risks of building and power plant components. Subject of the project are the foundations of wind turbines, which are subjected to high number of oscillating loads during operation. The project partner carries out vibration measurements on foundations. These should be used to characterize the current state. It is believed that fatigue damage caused by vibratory stress is reflected in a change in vibration behavior. The work undertaken at BOKU deals with the analysis of the measured velocity time series. A new algorithm shall automatically obtaine characteristic values ​​of the measured signals, which allow an analysis of the condition of the foundation.

Supervised Theses and Dissertations

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