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Research project (§ 26 & § 27)
Duration : 2017-07-01 - 2019-06-30

Cellular DNA is tightly packed with histones, proteins directly involved in regulation of gene expression with impact on numerous biological processes including cell differentiation, epigenetics and disease development. In particular, histones achieve this regulation by various types and combinations of post-translational modifications that are interpreted by interactions with specific effector proteins. Despite their pivotal role in different biological contexts, effects of histone modifications on recruitment of effectors at the atomistic level remains elusive. Here, our main goal is to further our understanding of microscopic mechanisms determining the function of histone modifications. To do this, we will use molecular dynamics simulations, a widely used high-resolution computational method for studying biomolecular properties and behavior at the atomistic level. More specifically, we intend to systematically investigate how different histone modifications and combinations thereof affect interactions with related effectors. In addition, histone effectors dedicated to recognition of lysine methylation and acetylation have been recently shown as promising targets for small molecule drugs. To this end, we intend to use molecular dynamics simulations to model interactions of effectors with known active molecules in order to examine binding mechanism as well as explore binding of other compounds by using perturbation free energy calculations.
Research project (§ 26 & § 27)
Duration : 2017-01-01 - 2019-12-31

In this project a new type of x-ray microscope with an x-ray “color” camera shall be procured and set up. It will allow for the first time the combination of full-field imaging of the chemical composition and 3D crystallographic analysis of materials with micrometer resolution. This method is of special interest for structurally and chemically inhomogeneous material. The areas of application range from biological systems (biomineralized tissues, self-assembly processes), the non-destructive study of art objects and thin film technology to industrial materials science (nanocomposite materials, nanocrystalline metal alloys etc.)
Research project (§ 26 & § 27)
Duration : 2016-03-01 - 2017-02-28

The aim of the project concerns the investigation of the state of the art extruder technology on hydrothermal carbonisation. Therefore, an experimental campaign on an existing extruder for food preparation with HTC process parameters is planned. Different mechanical components are investigated and adapted for the new process parameters. The moisture content of the feedstock is one variation parameter.

Supervised Theses and Dissertations